| Annotated protein: | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (GLUT1 C-terminal-binding protein) (GLUT1CBP) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin). Gene symbol: GIPC1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z254 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GIPC1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Yano H, et al. "BDNF-mediated neurotransmission relies upon a myosin VI motor complex" Nat Neurosci. 2006 Aug;9(8):1009-18 PMID:16819522 |
| Figure(s): | Fig.2 |
| Annotation description: | Figure 2 shows immuno-EM on GIPC1 in rodent hippocampus, which is found both in the pre- and post-synapse. Fig2c shows clear immunoreactivity by light microscopy in wild type which is not present in the Gipc1 null, indicating that the antibody is specific. Fig 2f and g show immunoreactivity in the presynapse by DAB and immunogold methods respectively. Panels e and h show immunoreactivity in the postsynaptic compartment with the same two methods. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 989 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |