| Annotated protein: | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle). Gene symbol: MYO5A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QYF3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MYO5A |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic actin cytoskeleton (GO:0098871) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Correia SS, et al. "Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation" Nat Neurosci. 2008 Apr;11(4):457-66 PMID:18311135 |
| Figure(s): | Fig. 2, 4c,d,f |
| Annotation description: | Myosin Va shows a partial colocalization with GluR1 and GluR2 subunits in primary neuronal cultures (Fig. 2a,b). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Microscopy (generic) Electrophysiology (generic) Biochemical fractionation (generic) IP + WB/MSMS |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| Additional literature: | The heavy chain of Myosin-Va (dilute myosin) was identified in the PSD fraction by mass spectrometry , Immunocytochemical localization of myosin-Va in cultured hippocampal neurons shows that it partially colocalizes with PSD-95 at synapses @ PMID:10818142 |
| SynGO annotation ID: | 984 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |