| Annotated protein: | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17). Gene symbol: CAMK2A. Taxonomy: Mus musculus (Mouse). Uniprot ID: P11798 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CAMK2A |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle docking (GO:0099148) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Hojjati MR, et al. "Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses" Nat Neurosci. 2007 Sep;10(9):1125-7 PMID:17660813 |
| Figure(s): | Figure 3, figure S4 |
| Annotation description: | Figure 3 shows that by quantitative electron microscopy that in slices from αCaMKII KO mice, asymmetric synapses on dendritic spines of CA1 pyramidal neurons, the number of docked vesicles is increased. Figure S4 shows example images. Figure 2d show that during a 10 Hz train, the depletion rate of SVs is lower in slices from αCaMKII KO mice. Taken together, these data point to a regulatory role of αCaMKII on synaptic vesicle docking. 2/7/2017 Pim - Important to note that this effect on SV docking is not depending on its catalytic activity. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Field recordings |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| Additional literature: | The paper describes a mouse where the alphaCaMKII isoform was deleted in presynaptic CA3 neurons and short-term plasticity was evaluated at the Ca1 postsynaptic neurons. Figure 3 shows that during high-frequency trains an enhancement in the activity, and in the activity-dependent increase of release probability is seen. @ PMID:12629219 |
| SynGO annotation ID: | 981 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |