| Annotated protein: | Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha). Gene symbol: CAMK1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63450 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CAMK1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse organization (GO:0050807) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Saneyoshi T, et al. "Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex" Neuron. 2008 Jan 10;57(1):94-107 PMID:18184567 |
| Figure(s): | Figure 2A, Figure 5A, D |
| Annotation description: | The paper characterizes a postsynaptic signal transduction pathway, where a CaMKK activates CaMKIalpha, which then binds to and phosphorylates βPIX. The signal transduction pathway likely operates during synaptogenesis. Figure 2D shows that CaMKIalpha phosphorylates Ser516 in βPIX. Figure 5A shows that the overexpression of a dominant-negative CaMKIalpha or of a phosphorylation-deficient βPIX reduce the spine-density. Figure 5D demonstrates an effect of the siRNA-mediated knock-down of CaMKIalpha on spinogenesis, whereas the knock-down of CaMKIbeta has no effect. |
| Evidence tracking, Biological System: | Cultured neurons Cell-free system |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 980 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |