| Annotated protein: | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1). Gene symbol: PPP3R1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q63810 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PPP3R1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | Parallel fibre (cerebellum -> Purkinje-cell) |
| Annotated paper: | Schonewille M, et al. "Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning" Neuron. 2010 Aug 26;67(4):618-28 PMID:20797538 |
| Figure(s): | Figure 2, 3 |
| Annotation description: | The role of PPP3R1 (called CNB1 in this article) is investigated using a mouse line that specifically knocks out PPP3R1 in Purkinje cells. In this mouse line, LTP is eliminated at the parallel fiber -> Purkinje cell synapse (figure 2A). Other synaptic parameters, including LTD (Figure 2) or paired pulse plasticity (Figure 3) are not affected. The names used for the mouse line are a confusing. PPP3R1 is a regulatory subunit of PP2B (calcineurin). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| SynGO annotation ID: | 972 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |