| Annotated protein: | Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin). Gene symbol: FLNA. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BTM8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FLNA |
| Ontology domain: | Biological Process |
| SynGO term: | synapse organization (GO:0050808) |
| Annotated paper: | Segura I, et al. "The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A" Cell Rep. 2016 Mar 22;14(11):2653-67 PMID:26972007 |
| Figure(s): | Figure 7 |
| Annotation description: | Knockdown of FLNA causes a reduction in spine density, increase in spine length and decrease in spine width, indicating a less mature spine morphology. Therefore I assigned the GO term modification of postsynaptic structure. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 950 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |