| Annotated protein: | Glutamate receptor-interacting protein 1 (GRIP-1). Gene symbol: GRIP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q925T6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRIP1 |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter receptor transport, endosome to postsynaptic membrane (GO:0098887) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Mao L, et al. "GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions" Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19038-43 PMID:20956289 |
| Figure(s): | Figure 1-5 |
| Annotation description: | This paper describes experiments on GRIP1/2 double-knockout neurons demonstrating that GRIP1 is required for activity-induced recycling of AMPARs (but not endocytosis or steady-state AMAPR surface levels), and that GRIP1 is associated with endosomes, as well as proteins of the exocyst complex targeting AMPAR-containing endosomes to the membrane. Together, these studies indicate that GRIP1 and 2 are required for AMPAR transport from endosomes to the postsynaptic membrane |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 948 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |