| Annotated protein: | Contactin-1 (Neural cell surface protein F3). Gene symbol: CNTN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P12960 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CNTN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | anchored component of postsynaptic membrane (GO:0099025) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Faivre-Sarrailh C, et al. "F3/F11 cell surface molecule expression in the developing mouse cerebellum is polarized at synaptic sites and within granule cells" J Neurosci. 1992 Jan;12(1):257-67 PMID:1729438 |
| Figure(s): | Figs. 2, 3, 4, 5 |
| Annotation description: | Fig 2, 3, 4, 5 Molecular layer Golgi Cell dendrites and dendritic spines were labelled with anti-contactin-1 antibodies in immunoEM of 10-day old and adult mice. Note that other neuron types exhibit presynaptic labeling (annotation 945), but that at no synapse both pre- and post-synaptic labeling was detected. 12/10/2017 Pim - Based on the known lipid anchor of the protein, the "anchored component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| Additional literature: | A hydrophobic analysis of contactin-1 revealed a stretch of nonpolar amino acids at its extreme C-terminus, indicative of attachment to the membrane via a GPI lipid anchor. Expression of human contactin-1 revealed plasma membrane expression by immunostaining. @ PMID:7959734 |
| SynGO annotation ID: | 946 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |