| Annotated protein: | Contactin-1 (Neural cell surface protein F3). Gene symbol: CNTN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P12960 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CNTN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | anchored component of presynaptic membrane (GO:0099026) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Faivre-Sarrailh C, et al. "F3/F11 cell surface molecule expression in the developing mouse cerebellum is polarized at synaptic sites and within granule cells" J Neurosci. 1992 Jan;12(1):257-67 PMID:1729438 |
| Figure(s): | Figs. 3, 5 |
| Annotation description: | Fig 3, 5: The parallel fibers and presynaptic varicosities in the molecular layer of cerebellum were stained in EM of 10-day old mouse. Fig 6: In the internal granular cell layer of the cerebellum, the mossy fiber terminals are stained Note that other neuron types exhibit postsynaptic labeling (annotation 946), but that at no synapse both pre- and post-synaptic labeling was detected. 12/10/2017 Pim - Based on the known lipid anchor of the protein, the "anchored component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| Additional literature: | A hydrophobic analysis of contactin-1 revealed a stretch of nonpolar amino acids at its extreme C-terminus, indicative of attachment to the membrane via a GPI lipid anchor. Expression of human contactin-1 revealed plasma membrane expression by immunostaining. @ PMID:7959734 |
| SynGO annotation ID: | 945 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |