| Annotated protein: | Teneurin-a (Tena) (Tenascin-like protein). Gene symbol: TEN-A. Taxonomy: Drosophila melanogaster (Fruit fly). Uniprot ID: Q9VYN8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TENM1 SynGO data @ TENM2 SynGO data @ TENM3 SynGO data @ TENM4 |
| Ontology domain: | Biological Process |
| SynGO term: | maintenance of alignment of postsynaptic density and presynaptic active zone (GO:0099559) |
| Annotated paper: | Mosca TJ, et al. "Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice" Nature. 2012 Mar 18;484(7393):237-41 PMID:22426000 |
| Figure(s): | Figs. 1, 2, 3 |
| Annotation description: | Loss of Teneurin-a reduces the apposition of active zones and neurotransmitter clusters at Drosophila neuromuscular junctions as show in Fig. 2. Fig.3a,c shows that Teneurin-a loss results in microtubule disorganization at the boutons of Drosophila neuromuscular junctions. In agreement with a presynaptic effect, Fig.1 shows that Teneurin-a is presynaptically localized at Drosophila NMJs. 6/11/2017 Pim - Teneurins are transsynaptic adhesion molecules that intracellularly couple to various components of the cytoskeleton. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 943 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |