| Annotated protein: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-beta-1) (PLC-beta-1). Gene symbol: PLCB1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9Z1B3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PLCB1 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Choi SY, et al. "Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex" J Neurosci. 2005 Dec 7;25(49):11433-43 PMID:16339037 |
| Figure(s): | Figure 6 |
| Annotation description: | The authors investigate the role of PLCs in long-term depression (LTD) in the visual cortex. They find that knockout of PLC-b1 abolishes LTD in this preparation (Figure 6A). This appears to be a postsynaptic effect, because postsynaptic superfusion with the PLC antagonist U73112 (U...2) also blocks LTD (Figure 6B). 24/11/2017 Pim - Since the authors investigate the site of action, I allow annotation to the postsynaptic process. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| SynGO annotation ID: | 941 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |