| Annotated protein: | Epidermal growth factor receptor kinase substrate 8. Gene symbol: EPS8. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q08509 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EPS8 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wang YT, et al. "Conditional deletion of Eps8 reduces hippocampal synaptic plasticity and impairs cognitive function" Neuropharmacology. 2017 Jan;112(Pt A):113-123 PMID:27450093 |
| Figure(s): | Fig. 3, Fig. 4B |
| Annotation description: | In synaptosomal fractions from hippocampal CA1 tissues GluN2B protein levels were significantly increased in Eps8-/- mice. 22/6/2017 Pim Fig.3 " Conditional deletion of Eps8 elevates synaptic GluN2B-containing NMDAR activity" Fig.4 "Conditional deletion of Eps8 increases synaptic GluN2B subunit expression" These two lines of evidence show that the number of receptor molecules in the synaptic density are increased. - ifenprodil used as Glun2B-selective antagonist |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist Antibody (detection) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Western blot Biochemical fractionation (generic) |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 930 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |