| Annotated protein: | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 1). Gene symbol: RIMS1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99NE5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RIMS1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic active zone cytoplasmic component (GO:0098831) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Wang SSH, et al. "Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking" Neuron. 2016 Aug 17;91(4):777-791 PMID:27537483 |
| Figure(s): | Figure 1B |
| Annotation description: | Using well characterized antibodies, it is demonstrated that RIM1 is present at the active zone. A knockout control is provided. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| SynGO annotation ID: | 93 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |