| Annotated protein: | Neurabin-2. Gene symbol: PPP1R9B. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: H9F1Y7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PPP1R9B |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | neocortex |
| Annotated paper: | Muly EC, et al. "Subcellular distribution of spinophilin immunolabeling in primate prefrontal cortex: localization to and within dendritic spines" J Comp Neurol. 2004 Feb 2;469(2):185-97 PMID:14694533 |
| Figure(s): | Fig2, Fig3, Fig6, Fig7 and Fig9 |
| Annotation description: | Synaptic Neurabin-2/Spinophilin is detected by immuno-EM in spines {Fig2A and E) as well as proximate glial processes (Fig2C). This is quantified in Fig3, no labelling has been observed in synaptic terminals (in contrast to Neurabin-1). Within the spine, Neurabin-2/Spinophilin is located to the PSD and the area in close proximity of the PSD (fig6, quantification in Fig7 and Fig9). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | This reference shows the quantitative immuno-EM of Neurabin-2/Spinophilin selectively to the spine without labelling to the synaptic terminals by the same group, but in an independent set of experiments. @ PMID:15217898 |
| SynGO annotation ID: | 914 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |