| Annotated protein: | CED-5 (Dedicator of cytokinesis protein 1). Gene symbol: CED-5. Taxonomy: Caenorhabditis elegans (Worm). Uniprot ID: G5EEN3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DOCK1 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle clustering (GO:0097091) |
| Annotated paper: | Stavoe AK, et al. "Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton" J Cell Biol. 2012 Apr 2;197(1):75-88 PMID:22451697 |
| Figure(s): | Figs 2C, D and G |
| Annotation description: | ced5 mutants exhibit synaptic vesicle clustering defects in AIY interneurons (assessed using confocal microscopy imaging of wild type and mutant worms expressing RAB3-GFP). CED5 effect on SV clustering depends on UNC-40 localisation. CED5 acts through the GTPase CED10 and, in turn, through MIG10. Like ced5 mutants, both ced10 (Figs 3H, I and N) and mig10 mutants (Figs 4C, E and F) also display SV clustering defects that may occur via organisation of presynaptic actin. Neither ced5 nor mig10 mutants affect localisation of active zone proteins SYD1 and SYD2. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| SynGO annotation ID: | 902 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |