| Annotated protein: | Neurexin-1-beta (Neurexin I-beta). Gene symbol: NRXN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P0DI97 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRXN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Chamma I, et al. "Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy" Neurophotonics. 2016 Oct;3(4):041810 PMID:27872870 |
| Figure(s): | Figs. 1, 2, 3 |
| Annotation description: | The authors use super-resolved tracking of a tagged Neurexin-1beta in live cultured hippocampal neurons. The results show that Neurexin-1beta sorts to presynaptic sites (Fig. 1), where it forms 1 to 2 nanoclusters per terminal while a dispersed population is additionally present in terminals (Fig. 1, 2, 3). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| Additional literature: | The authors performed super-resolved tracking of a Neurexin-1beta construct that was tagged differently than in the primary reference of this annotation. The results in Fig. 5 support that presynaptic sites contain Neurexin-1beta clusters in live cultured hippocampal neurons. @ PMID:26979420 Fig. 5 and Table 1 of this study support the localization of Neurexin-1beta to presynaptic membranes as determined by the biochemical sub-fractionation of synaptosomes and immunoblotting. @ PMID:17868325 |
| SynGO annotation ID: | 900 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |