| Annotated protein: | Potassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (EAG1) (r-eag) (Voltage-gated potassium channel subunit Kv10.1). Gene symbol: KCNH1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63472 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNH1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Mortensen LS, et al. "KV 10.1 opposes activity-dependent increase in Ca(2)(+) influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse" J Physiol. 2015 Jan 1;593(1):181-96 PMID:25556795 |
| Figure(s): | fig 3a |
| Annotation description: | Immunogold labeling shows localisation close to the presynaptic plasmamembrane and in the cytosol. Since it is a channel its expected location is in the membrane. 5/12/2016 Pim: - integral component in the annotation is derived from TM-domains in the annotated protein. - Literal excerpt: "Gold particles (5 nm in diameter) are localized in the presynaptic terminal close to the presynaptic plasma membrane (arrowhead) and within the cytoplasm of the PF synapse (arrow)" [5/12/2016 Pim] - Fig 3b shows presynaptic localization in the **mouse** by using a biochemical approach. This annotation was omitted for now. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 9 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |