| Annotated protein: | Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha). Gene symbol: NRXN3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6P9K9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRXN3 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | olfactory bulb, GABAergic |
| Annotated paper: | Aoto J, et al. "Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses" Nat Neurosci. 2015 Jul;18(7):997-1007 PMID:26030848 |
| Figure(s): | Figs. 6, 7, Supplementary Fig. 2e & 2f |
| Annotation description: | In inhibitory olfactory bulb synapses, the neurexin-3a/b deletion caused a selective decrease in presynaptic GABA release (Fig. 7) without a change in postsynaptic receptor composition (Fig. 6). 1/11/2017 Pim - The paper uses DKO of neurexin-3alpha and neurexin-3beta genes (Fig.6/7) Data on the neurexin-3alpha is also included in Supplementary Fig. 2. Overall, the data for this paper directly supports a role for neurexin-3alpha, and a IGI relation of neurexin-3beta that is based on supposed functional redundancy between paralogs and author intent. - Authors note: '"The constitutive ablation of Nrxn3α phenocopied the GABA release phenotype observed in Nrxn3α/β cKO cultured olfactory bulb neurons, suggesting that only Nrxn3α is essential for GABA release in granule cell neurons" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| Additional literature: | This study highlights that neurexins have diverse functional roles that are synapse-type specific. Functional roles of individual neurexins are therefore not generally applicable across synapses types. @ PMID:28472659 |
| SynGO annotation ID: | 897 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |