| Annotated protein: | Neurexin-1-beta (Neurexin I-beta). Gene symbol: NRXN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P0DI97 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRXN1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission (GO:0150036) |
| Synapse type(s): | neocortex |
| Annotated paper: | Anderson GR, et al. "beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling" Cell. 2015 Jul 30;162(3):593-606 PMID:26213384 |
| Figure(s): | Figs. 3, 4 |
| Annotation description: | Neurexin-1beta without an insert in splice site 4 (SS4-) regulates mEPSC frequency in cultured cortical neurons. Fig. 3 shows that this isoform rescues the decrease in mEPSC frequency that occurs in cultured triple neurexin-1/2/3beta KO neurons. Fig. 4 shows that the decrease in mEPSC frequency in absence of all beta-neurexins is correlated with an increase in endocannabinoid signaling that originates in the postsynaptic neurons. This indicates that the abovementioned presynaptic neurexin-1beta rescue of excitatory miniature release may involve a regulation of postsynaptic endocannabinoid signaling. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| Additional literature: | This study highlights that neurexins have diverse functional roles that are synapse-type specific. Functional effects of individual neurexins are therefore not generally applicable across synapses types. @ PMID:28472659 |
| SynGO annotation ID: | 895 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |