Annotated protein:Profilin-1 (Profilin I). Gene symbol: PFN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62963
antibody wiki:
SynGO gene info:SynGO data @ PFN1
Ontology domain:Cellular Component
SynGO term:postsynapse (GO:0098794)
Synapse type(s):Schaffer collateral synapse (CA3->CA1)
Parallel fibre (cerebellum -> Purkinje-cell)
Annotated paper:Neuhoff H, et al. "The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner" Eur J Neurosci. 2005 Jan;21(1):15-25 PMID:15654839
Figure(s):Fig3, Fig4 and Fig5
Annotation description:Profilin-1 is detected in the the presynapse of rat hippocampus CA1 [Fig3D] and cerebellar cortex [Fig4B & C] as well as the spine in CA1 [Fig3B-D]. The presentence profilin-1 at both the pre- and postsynaptic side was also observed in cultured mouse hippocampal neurons [Fig 5A-C]. The localisation of the immuno-gold label are consistent with the role of profilins as actin regulators.
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Jan van Weering (ORCID:0000-0001-5259-4945)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:891
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology