| Annotated protein: | Profilin-1 (Profilin I). Gene symbol: PFN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62963 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PFN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) Parallel fibre (cerebellum -> Purkinje-cell) |
| Annotated paper: | Neuhoff H, et al. "The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner" Eur J Neurosci. 2005 Jan;21(1):15-25 PMID:15654839 |
| Figure(s): | Fig3, Fig4 and Fig5 |
| Annotation description: | Profilin-1 is detected in the the presynapse of rat hippocampus CA1 [Fig3D] and cerebellar cortex [Fig4B & C] as well as the spine in CA1 [Fig3B-D]. The presentence profilin-1 at both the pre- and postsynaptic side was also observed in cultured mouse hippocampal neurons [Fig 5A-C]. The localisation of the immuno-gold label are consistent with the role of profilins as actin regulators. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Shows profilin as actin-interacting protein 19/6/2017 Pim - Note this is not shown in this paper. @ PMID:10601251 |
| SynGO annotation ID: | 890 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |