Annotated protein:Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65). Gene symbol: APBB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P46933
antibody wiki:
SynGO gene info:SynGO data @ APBB1
Ontology domain:Cellular Component
SynGO term:presynapse (GO:0098793)
Synapse type(s):cerebral cortex
Annotated paper:Sabo SL, et al. "The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo" J Neurosci. 2003 Jul 2;23(13):5407-15 PMID:12843239
Figure(s):Figs 5, 6 and 7
Annotation description:Confocal images of neurons stained with antibodies against APBB1/Fe65 and synaptophysin shows colocalisation of both proteins in a synaptic staining pattern. Live-imaging experiments further illustrate punctate colocalisation of APBB1-EGFP and with synaptobrevin-DsRed puncta in axons.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Confocal
Annotator(s):John Chua (ORCID:0000-0002-5615-1014)
Lab:Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore
SynGO annotation ID:880
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology