| Annotated protein: | Mu-type opioid receptor (M-OR-1) (MOR-1) (Opioid receptor B). Gene symbol: OPRM1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P33535 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ OPRM1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | striatum |
| Annotated paper: | Wang H, et al. "Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors" J Neurosci. 2001 May 1;21(9):3242-50 PMID:11312309 |
| Figure(s): | Figure1, Figure 2, Figure 4b,c, Figure 6 |
| Annotation description: | The paper characterizes the sub cellular localization of both mu-type and delta-type opioid receptors using immuogold-silver and peroxidase labelling. Figure 1 is a quantification of the labelled profiles, showing a very high labeling rate at dendritic spines. Figure 2 presents a quantification, showing that in labelled spines, a large proportion of mu-type immunolabeling is at the membrane. Figure 4b,c show two profiles of spines with mu-type immunoreactivity. The immunoreactivity is mostly at the extrasyanptic membrane. Figure 6 is a scheme illustrating the main sub cellular localization of the receptors. 2/7/2017 Pim - Literal: "In contrast to DOR, MOR was preferentially localized to the extrasynaptic plasma membrane of dendrites and spines" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| Additional literature: | The paper describes the localization of mu-type opioid receptors at the Shell of the Rat Nucleus Accumbens. mu-type opioid receptors labeling was localized mainly to extrasynaptic plasma membranes at the post-synaptic neurons. @ PMID:9169542 |
| SynGO annotation ID: | 873 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |