| Annotated protein: | Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2). Gene symbol: APBA2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P98084 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ APBA2 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Ho A, et al. "Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family" J Neurosci. 2006 Dec 13;26(50):13089-101 PMID:17167098 |
| Figure(s): | Figs. 5, 6, 7 |
| Annotation description: | Mint2 likely functions redundantly with Mint1 in excitatory neurons to regulate presynaptic release at excitatory synapses. Fig. 5 shows that Mint1/2 DKO mice but not single Mint1 KO mice exhibit reduced basal excitatory synaptic strength and a decrease in neurotransmitter release probability at excitatory synapses. Fig. 6 shows that release probability is normal at inhibitory synapses of Mint1/2 DKO mice. Fig. 7 shows that Mint1/2 DKO mice have reduced mEPSC frequency. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 871 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |