| Annotated protein: | Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein homolog) (HPS7 protein homolog). Gene symbol: DTNBP1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q91WZ8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DTNBP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | synaptic vesicle membrane (GO:0030672) |
| Synapse type(s): | hippocampus Schaffer collateral synapse (CA3->CA1) Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Talbot K, et al. "Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin" Hum Mol Genet. 2006 Oct 15;15(20):3041-54 PMID:16980328 |
| Figure(s): | Fig2, Fig3 Fig5, Fig6, Fig7 and Fig8 |
| Annotation description: | By tissue fractionation of mouse whole brain [Fig2] or human post mortem hippocampus [Fig3], DTNBP1 (Dysbindin-1) is found concentrated in the synaptosome and synaptic vesicle fractions, with little protein in the PSD fraction. Immuno-EM (qualitative) confirmed presynaptic vesicle localisation in the mouse and macaque dentate gyrus inner molecular layer [Fig5] and CA1 [Fig8A & B], and the dentate gyrus hilus of the mouse [Fig6C]. Postsynaptic density localisation was also detected in the dentate gyrus hilus [Fig6B & D] mossy fiber synapse [Fig7] and in the CA1 area of mouse [Fig8D & E]. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Biochemical fractionation (generic) |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 866 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |