| Annotated protein: | Kappa-type opioid receptor (K-OR-1) (KOR-1). Gene symbol: OPRK1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P34975 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ OPRK1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | striatum |
| Annotated paper: | Svingos AL, et al. "Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles" Synapse. 2001 Dec 1;42(3):185-92 PMID:11746715 |
| Figure(s): | Figure 4 and table 1 |
| Annotation description: | The paper examines the localization of kappa-type opioid receptor in dopaminergic terminals at the nucleus Accumbens using electron microscopic immunocytochemistry. Fig. 4 shows a DAT-containing terminal in contact with kappa-type immunoreactive dendritic spines. The dendritic spine shows kappa-type opioid receptor labeling at the postsynaptic density and along extrasynaptic portions of the plasma membrane. The fraction of kappa-type opioid receptor immunoreactivities which opposes DAT labeling is quantified in table 1. 2/7/2017 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 863 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |