| Annotated protein: | Kappa-type opioid receptor (K-OR-1) (KOR-1). Gene symbol: OPRK1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P34975 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ OPRK1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | striatum |
| Annotated paper: | Svingos AL, et al. "Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles" Synapse. 2001 Dec 1;42(3):185-92 PMID:11746715 |
| Figure(s): | Table 1, figures 1-3 |
| Annotation description: | The paper examines the localization of kappa-type opioid receptor in dopaminergic terminals at the nucleus Accumbens using electron microscopic immunocytochemistry. Figure 1, 2 and 3 present immunoreactivities for kappa-type opioid receptors in axon terminals, partially localizing to DAT immunoreactivities (quantified in figure 1). The immunostaining is found at the axonal plasma membrane and at the membrane of small SVs. 2/7/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 861 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |