Annotated protein:Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2). Gene symbol: ATP2B2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P11506
antibody wiki:
SynGO gene info:SynGO data @ ATP2B2
Ontology domain:Cellular Component
SynGO term:integral component of postsynaptic membrane (GO:0099055)
Synapse type(s):cerebellum, glutamatergic
Parallel fibre (cerebellum -> Purkinje-cell)
Annotated paper:Burette A, et al. "Perisynaptic organization of plasma membrane calcium pumps in cerebellar cortex" J Comp Neurol. 2007 Feb 20;500(6):1127-35 PMID:17183553
Figure(s):Fig. 2
Annotation description:Silver-enhanced immunogold-labeling of the Spine plasma membrane (Term not among the offered GO-Terms).
fig. 2 C: Pooled measurements of 133 gold/ silver particles (from 38 randomly selected spine profiles) show that immunolabeling concentrates in a region 200 -300 nm away from the edge of the PSD. D: The same data, normalized to compensate for variable sizes of the spine profiles (as suggested by the ratio of the red
line to the green line in cartoon; see Materials and Methods for equation). E: Gold/silver particles are at highest density at the spine tip (data normalized to compensate for variations in spine sizes, see
cartoon).
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Daniela Dieterich (ORCID:0000-0002-9880-1214)
Rainer Pielot (ORCID:0000-0002-9681-3318)
Karl-Heinz Smalla (ORCID:0000-0002-0269-0311)
Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:86
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology