| Annotated protein: | Neuronal pentraxin receptor. Gene symbol: NPTXR. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99J85 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NPTXR |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0099645) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Lee SJ, et al. "Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses" J Neurosci. 2017 Feb 1;37(5):1062-1080 PMID:27986928 |
| Figure(s): | Figs. 1, 2, 5, 10, 11 |
| Annotation description: | Presynaptic NPR directly binds to the GluA1-N terminal extracellular domain and stimulates assembly of both excitatory and inhibitory postsynaptic sites. Loss of NPR suppressed surface GluA1 levels, and impaired excitatory synaptic transmission, without affecting synapse numbers. Figs.1 and 5 support that NPR is involved in formation of postsynaptic specializations. Fig.2 shows that NPR binds the GluA1-NTD. Figs.10 and 11 show that global NPR knockdown in pre- and post-synaptic neurons impairs excitatory postsynaptic scaffold assembly and the strength of excitatory transmission. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal Electrophysiology (generic) IP + WB/MSMS |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 849 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |