| Annotated protein: | Signal transducer and activator of transcription 3. Gene symbol: STAT3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P52631 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STAT3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | Murata S, et al. "Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain" Brain Res Mol Brain Res. 2000 May 31;78(1-2):80-90 PMID:10891587 |
| Figure(s): | Fig 1, Fig 4, Fig 5, Fig 6. |
| Annotation description: | Authors examined the distribution of STAT3 in the rat brain. Using western blotting and subcellular fractionation authors found STAT3 immunoreactivity in the various subcellular fractions, including synaptic fractions. Then, they performed electron microscopy in the cerebral cortex with DAB enhancement, with and without post-staining to enhance visualization of some structures. By doing this, authors found PSDs and subsynaptic regions strongly labelled, though non-immunoreactive PSDs were also observed. Presynaptic terminals were not labelled. Moreover, authors also found phosphorylation of STAT3 in PSD fractions, which suggest that STAT3 signaling occurs at postsynaptic sites. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Western blot Biochemical fractionation (generic) |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 838 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |