| Annotated protein: | Profilin-2 (Profilin II). Gene symbol: PFN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9JJV2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PFN2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Pilo Boyl P, et al. "Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior" EMBO J. 2007 Jun 20;26(12):2991-3002 PMID:17541406 |
| Figure(s): | Fig1C |
| Annotation description: | Fig1C: quantitative immuno-EM for endogenous Profilin2. The pfn2 KO mouse was used as control. Quantification shows that profilin 2 is predominantly localised to the postsynaptic spine, with also significant labelling in presynaptic boutons and dendritic spines compared to background labelling in the pfn2 null mice. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 822 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |