Annotated protein:	Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6). Gene symbol: SLC6A6. Taxonomy: Mus musculus (Mouse). Uniprot ID: O35316
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SynGO gene info:	SynGO data @ SLC6A6
Ontology domain:	Cellular Component
SynGO term:	integral component of postsynaptic membrane (GO:0099055)
Synapse type(s):	striatum, GABAergic
Annotated paper:	Sergeeva OA, et al. "GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition" J Physiol. 2007 Dec 1;585(Pt 2):539-48 PMID:17962336
Figure(s):	Fig.1C
Annotation description:	The taurine transporter is an integral membrane protein (see reference) and localizes in cultured striatal neurons to cell bodies and dendrites (co-localization with MAP2). Antibody: rabbit anti-taurine transporterserum Tau11-A (DPC Biermann, Bad Nauheim, Germany,1 : 500); No KO control. 21/8/2017 Pim - The synapse localization is in part evidenced by the effect of the TAUT KO on synapse physiology. This means that the dendritic localization is "postsynaptic". - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:	Cultured neurons
Evidence tracking, Protein Targeting:	Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection)
Evidence tracking, Experiment Assay:	Microscopy (generic) Whole-cell patch clamp
Annotator(s):	Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534)
Lab:	Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany
Additional literature:	Cloning of the taurine transporter and radiolabelled taurine uptake measurements in COS cells. @ PMID:1435737
SynGO annotation ID:	817
Dataset release (version):	20231201
View annotation as GO-CAM model: