Annotated protein:Profilin-2 (Profilin II). Gene symbol: PFN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9JJV2
antibody wiki:
SynGO gene info:SynGO data @ PFN2
Ontology domain:Cellular Component
SynGO term:postsynapse (GO:0098794)
Synapse type(s):Schaffer collateral synapse (CA3->CA1)
Annotated paper:Pilo Boyl P, et al. "Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior" EMBO J. 2007 Jun 20;26(12):2991-3002 PMID:17541406
Figure(s):Fig1C
Annotation description:Fig1C: quantitative immuno-EM for endogenous Profilin2. The pfn2 KO mouse was used as control. Quantification shows that profilin 2 is predominantly localised to the postsynaptic spine, with also significant labelling in presynaptic boutons and dendritic spines compared to background labelling in the pfn2 null mice.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Jan van Weering (ORCID:0000-0001-5259-4945)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:800
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology