| Annotated protein: | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit). Gene symbol: CDK5. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q03114 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDK5 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of presynaptic cytosolic calcium levels (GO:0099509) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Kim SH, et al. "Balance of calcineurin Aalpha and CDK5 activities sets release probability at nerve terminals" J Neurosci. 2013 May 22;33(21):8937-50 PMID:23699505 |
| Figure(s): | 3D-E, 6G |
| Annotation description: | Combination of knock down and pharmacological inhibitions along with function measures of presynaptic calcium influx shows that CDK5 normally constrains the activity of voltage-gated Ca channels. 23/01/2017 Pim - Fig.1 KD of CNa has negative effect on SV exocytosis - Fig.2 KD/agonist of CDK5 has positive effect on SV exocytosis - Fig.2 Effect of CDK5 and CNa is via VGCCs (shown via VGCC inhibition) - Fig.3/4/5/6 CNa and CDK5 activities affect presynaptic Ca influx |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antibody (detection) |
| Evidence tracking, Experiment Assay: | Optical physiology |
| Annotator(s): | Ryan J. Farrell (ORCID:0000-0003-4022-8707) Ghazaleh Ashrafi (ORCID:0000-0001-7480-0826) Camila Pulido (ORCID:0000-0002-5648-066X) Jaime de Juan-Sanz (ORCID:0000-0002-1212-5623) Timothy Ryan (ORCID:0000-0003-2533-9548) |
| Lab: | Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA |
| Additional literature: | PMID:11923424 |
| SynGO annotation ID: | 80 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |