| Annotated protein: | Leucine-rich repeat transmembrane neuronal protein 2 (Leucine-rich repeat neuronal 2 protein). Gene symbol: LRRTM2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D4A7P2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRRTM2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic density assembly (GO:0099151) |
| Synapse type(s): | hippocampus, glutamatergic brain |
| Annotated paper: | Linhoff MW, et al. "An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers" Neuron. 2009 Mar 12;61(5):734-49 PMID:19285470 |
| Figure(s): | Fig.2, Fig.3, Fig.4 |
| Annotation description: | Fig. 6 LRRTM2 mediates excitatory postsynaptic differentiation Literal: "The antibody-coated beads induced robust clustering of YFP-LRRTMs at nonsynaptic sites (sites lacking VGLUT1 or VGAT) on the dendrites. Such artificial clustering of YFP-LRRTMs resulted in coclustering of the glutamatergic postsynaptic proteins NMDA receptor essential subunit NR1 (Figures 6A and 6B), PSD-95 family (Figures 6C). In contrast, artificial clustering of YFP-LRRTMs did not result in coclustering of the inhibitory postsynaptic protein gephyrin (Figures 6D)" 8/6/2017 Pim - Postsynaptic density is inferred form aggregation of both NR1 and PSD95 proteins, markers of synaptic densities. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 796 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |