Annotated protein:Excitatory amino acid transporter 5 (Retinal glutamate transporter) (Solute carrier family 1 member 7). Gene symbol: SLC1A7. Taxonomy: Homo sapiens (Human). Uniprot ID: O00341
antibody wiki:
SynGO gene info:SynGO data @ SLC1A7
Ontology domain:Biological Process
SynGO term:neurotransmitter uptake (GO:0001504)
Annotated paper:Arriza JL, et al. "Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance" Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4155-60 PMID:9108121
Figure(s):Figure 3 and table 1
Annotation description:In the paper the isolation of the EAAT5, an excitatory amino acid transporter is described.

In figure 3 the uptake of 3H-L-glutamate and 3H-L-Aspertate are demonstrated in oocytes injected with the EAAT5 mRNA and voltage-clamped at -60 mV. In comparison to controls (uninjected oocytes), the uptake was typically 2- to 10-fold larger. The uptake is sodium- and voltage-dependent.
These data indicate that the transporter functions as a glutamate transporter.
Table 1 summarizes specificity and kinetic values of the transporter.

rule: NAS_MFCC-BP
rationale:
Protein has "glutamate transmembrane transporter activity" and is localized in the presynaptic membrane (show with high-resolution technique). The inference to term 'neurotransmitter uptake (GO:0001504)' is trivial and non-controversial.
Pinf_CC:
[Q8JZR4] SynGO ID 790 (PMID:23049999, EM)
Evidence tracking, Biological System:Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Transmembrane transport assay
Non-tracable Author Statement (NAS):This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors.
Annotator(s):Noa Lipstein (ORCID:0000-0002-0755-5899)
Cordelia Imig (ORCID:0000-0001-7351-8706)
Vincent O'connor (ORCID:0000-0003-3185-5709)
Nils Brose (ORCID:0000-0003-0938-8534)
Lab:Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany
SynGO annotation ID:791
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology