Annotated protein:Excitatory amino acid transporter 5 (Solute carrier family 1 member 7). Gene symbol: SLC1A7. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8JZR4
antibody wiki:
SynGO gene info:SynGO data @ SLC1A7
Ontology domain:Cellular Component
SynGO term:integral component of presynaptic membrane (GO:0099056)
Synapse type(s):cochlea, glutamatergic
Annotated paper:Dalet A, et al. "Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings" PLoS One. 2012;7(9):e46261 PMID:23049999
Figure(s):Figure 5,6 and Table 1
Annotation description:The paper characterizes the expression of EAAT4 and EAAT5 in the vestibular type I hair cells. These cells have post-synaptic calycal endings which restrict the diffusion of glutamate following endocytosis, so that uptake of glutamate by supporting cells is not plausible.

Figure 5: immunogold-labelling electron microscopy leads to the finding that the hair cells, as well as the calycal membrane facing the synaptic cleft, both harbor EAAT4 and EAAT5, supporting the notion that the transporters are located at both the pre- and postsynaptic membranes.
Table 1 presents the quantification of the immuogold labeling.
Figure 6 is a summarizing scheme.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Noa Lipstein (ORCID:0000-0002-0755-5899)
Cordelia Imig (ORCID:0000-0001-7351-8706)
Vincent O'connor (ORCID:0000-0003-3185-5709)
Nils Brose (ORCID:0000-0003-0938-8534)
Lab:Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany
SynGO annotation ID:790
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology