| Annotated protein: | Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6). Gene symbol: SLC1A6. Taxonomy: Homo sapiens (Human). Uniprot ID: P48664 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC1A6 |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter uptake (GO:0001504) |
| Annotated paper: | Fairman WA, et al. "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel" Nature. 1995 Jun 15;375(6532):599-603 PMID:7791878 |
| Figure(s): | Table 1 |
| Annotation description: | The paper charactrerizes EAAT4 as a L-glutamate and L-aspartate transporter that shuttles these across membranes in a sodium-dependent manner. Table 1 summarized the results of an 3H-L-glutamate and 3H-L-aspartate uptake assays in Xenopus oocytes expressing the transporter. Injected oocytes had a 30-fold higher uptake of the compounds than uninjected controls. |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Transmembrane transport assay |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 787 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |