| Annotated protein: | Neurocan core protein (245 kDa early postnatal core glycoprotein) (Chondroitin sulfate proteoglycan 3) [Cleaved into: 150 kDa adult core glycoprotein]. Gene symbol: NCAN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P55067 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NCAN |
| Ontology domain: | Cellular Component |
| SynGO term: | synapse (GO:0045202) |
| Synapse type(s): | forebrain cerebellum |
| Annotated paper: | Cheng D, et al. "Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum" Mol Cell Proteomics. 2006 Jun;5(6):1158-70 PMID:16507876 |
| Figure(s): | Table S2 |
| Annotation description: | A total of 296 proteins were identified in a PSD preparation from forebrain or cerebellum by LC-MS/MS. Among these neurocan (CSPG3) was identified. As neurocan is generally described as extracellular matrix components we consider the protein as part of the perisynaptic or synaptic extracellular matrix. 13/10/2017 Pim - Since this data concerns High Throughput Data SynGO does not allow inference to a more specific term. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | NCAN_RAT was also found in other PSD preparations (suppl. Table S1). @ PMID:14720225 |
| SynGO annotation ID: | 781 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |