| Annotated protein: | Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3). Gene symbol: RIMS3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9JIR3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RIMS3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | cerebellum hippocampus spinal cord |
| Annotated paper: | Liang F, et al. "RIM3gamma is a postsynaptic protein in the rat central nervous system" J Comp Neurol. 2007 Aug 1;503(4):501-10 PMID:17534942 |
| Figure(s): | Figure 5 |
| Annotation description: | Using an custom made antibody, it is shown that RIM3gamma is present at the postsynapse. Although the antibody recognizes overexpressed as well as endogenous RIM3 gamma as shown in the paper. A knockout control is currently not available. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Alvarez-Baron et.al. used biochemical fractionation and confocal microscopy to study the localization of RIM3gamma. Their findings are largely in line with Liang et.al., but are of lower resolution. @ PMID:23303958 |
| SynGO annotation ID: | 77 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |