| Annotated protein: | Src substrate cortactin. Gene symbol: CTTN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q66HL2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CTTN |
| Ontology domain: | Biological Process |
| SynGO term: | modification of postsynaptic actin cytoskeleton (GO:0098885) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hering H, et al. "Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis" J Neurosci. 2003 Dec 17;23(37):11759-69 PMID:14684878 |
| Figure(s): | Figures 1, 3 |
| Annotation description: | This paper describes how "knockdown of cortactin by short-interfering RNA (siRNA) results in a decrease of dendritic spines in hippocampal neurons, whereas overexpression of cortactin causes elongation of spines. In response to synaptic stimulation and NMDA receptor activation, cortactin redistributes rapidly from spines to dendritic shaft, correlating with remodeling of the actin cytoskeleton, implicating cortactin in the activity-dependent regulation of spine morphogenesis." Thus, cortactin seems implicated in spine morphology maintenance and activity-induced reorganization. Therefore, I chose the GO term "regulation of synapse organization" to combine these two functions. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 766 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |