| Annotated protein: | Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Sodium- and chloride-dependent GABA transporter 4) (GAT-4) (Solute carrier family 6 member 11). Gene symbol: SLC6A11. Taxonomy: Mus musculus (Mouse). Uniprot ID: P31650 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SLC6A11 |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter uptake (GO:0001504) |
| Annotated paper: | Liu QR, et al. "Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected" J Biol Chem. 1993 Jan 25;268(3):2106-12 PMID:8420981 |
| Figure(s): | Figure 2 |
| Annotation description: | The paper reports the identification of the GABA transporters GAT-3 and GAT-4. Figure 2 demonstrates the uptake Kinetics of 3H-GABA (2A), 3H-beta-alanine (2B), and 3H-taurine (3C) into Xenopus oocytes injected with synthetic mRNA of GAT3. This suggests that GAT3 is the transporter of GABA, beta-alanine, and taurine. rule: NAS_MFCC-BP rationale: Protein has "gamma-aminobutyric acid transmembrane transporter activity (GO:0015185)" and is localized in the presynaptic membrane (show with high-resolution technique). The inference to term 'neurotransmitter uptake (GO:0001504)' is trivial and non-controversial. Pinf_CC: [P31647] SynGO ID 768 (PMID:24368619, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | radioisotope assay evidence Transmembrane transport assay |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 763 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |