Annotated protein:Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9). Gene symbol: SLC6A9. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P28572
antibody wiki:
SynGO gene info:SynGO data @ SLC6A9
Ontology domain:Cellular Component
SynGO term:integral component of postsynaptic membrane (GO:0099055)
Synapse type(s):neocortex
Mossy fiber synapse (DG->CA3)
Parallel fibre (cerebellum -> Purkinje-cell)
Annotated paper:Cubelos B, et al. "Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain" Cereb Cortex. 2005 Apr;15(4):448-59 PMID:15749988
Figure(s):Figure 6
Annotation description:Immunohistochemical analysis of GlyT1 expression in neurons.
Figure 6 A-F: Pre-embedding immunogold staining of GLYT1 in the hippocampus the neocortex, and the spinal cord.
Figure 6 G-I, K: Post-embedding immunogold of GLYT1 in the dentate gyrus and the molecular layer of the cerebellum.
The profiles show localization in both the pre- and postsynaptic compartments, as well as in glial processes.
Figure 6G shows post-embedding immunogold staining for GLYT1 at the post synaptic density.
Figure 6J shows double post-embedding immunogold labeling for GLYT1 and NMDAR in the hippocampus, and demonstrates colocalization at the postsynaptic density.

2/7/2017 Pim
- Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Noa Lipstein (ORCID:0000-0002-0755-5899)
Cordelia Imig (ORCID:0000-0001-7351-8706)
Vincent O'connor (ORCID:0000-0003-3185-5709)
Nils Brose (ORCID:0000-0003-0938-8534)
Lab:Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany
SynGO annotation ID:743
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology