| Annotated protein: | Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (EC 3.2.2.6) (X-linked interleukin-1 receptor accessory protein-like 1). Gene symbol: IL1RAPL1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P59824 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ IL1RAPL1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic brain, glutamatergic |
| Annotated paper: | Pavlowsky A, et al. "A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation" Curr Biol. 2010 Jan 26;20(2):103-15 PMID:20096586 |
| Figure(s): | Fig. 1i and fig. 2c |
| Annotation description: | Fig. 1i IL1RAPL1 coimmunoprecipitates with PSD-95 Fig. 2c Il1RAPL1 colocalizes with PSD-95 Literal: "Finally, the interaction between IL1RAPL1 and PSD-95 was biochemically proven by pull-down and immunoprecipitation experiments in transfected COS-7 cells and in vivo from neuronal protein extract." "The endogenous IL1RAPL1 mostly colocalized with PSD-95 and Shank proteins (percent of IL1RAPL1 colocalization with PSD-95" 7/6/2017 Pim - PSD-95 is a marker protein for glutamatergic synapses. - IL1RAPL1 has a TM domain. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Protein-protein interaction (generic) |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 722 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |