| Annotated protein: | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13). Gene symbol: PRKCA. Taxonomy: Mus musculus (Mouse). Uniprot ID: P20444 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRKCA |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle exocytosis (GO:2000300) |
| Synapse type(s): | Calyx of Held |
| Annotated paper: | Fioravante D, et al. "Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held" Neuron. 2011 Jun 9;70(5):1005-19 PMID:21658591 |
| Figure(s): | Figure 2, Figure 3 |
| Annotation description: | It is demonstrated that a PKC alpha knockout has a reduction in post-tetanic potentiation (PTP), in the Calyx of Held. It is also shown that PTP operates at least partly due to a potentiation in readily releasable pool size, and that this potentiation is diminished in the PKC alpha/beta knockout. It should be noted that in some synapses, PKC alpha is not required for PTP (Wang et.al. 2016). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Wang et.al. demonstrates that the role of PKC alpha in PTP is not universal. In this publication, PKC alpha knockout has no effect on PTP at the CA3 to CA1 synapse. @ PMID:27307229 |
| SynGO annotation ID: | 70 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |