| Annotated protein: | Chromatin modifying protein 4B-like 1. Gene symbol: CHMP4BL1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D4A9Z8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CHMP4B |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | brain |
| Annotated paper: | Chassefeyre R, et al. "Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B" J Neurosci. 2015 Feb 18;35(7):3155-73 PMID:25698751 |
| Figure(s): | Fig 8a,b,d |
| Annotation description: | Authors found CHMP4B present in synaptoneurosomal fractions from rat cortical lysates and highly enriched in PSDI fractions. PSDI fractions are the insoluble material obtained by treating synaptoneuronamal fractions with Triton X100. Unlike PSD95, CHMP4B was solubilized after treatment of this fraction with more stringent detergents, suggesting that it is a peripherally attached PSD protein. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 687 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |