| Annotated protein: | Ring finger protein 216. Gene symbol: RNF216. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZU60 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RNF216 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Mabb AM, et al. "Triad3A regulates synaptic strength by ubiquitination of Arc" Neuron. 2014 Jun 18;82(6):1299-316 PMID:24945773 |
| Figure(s): | Fig 6 |
| Annotation description: | * Immunogold electron microscopy (EM) of rat CA1 hippocampus in vivo shows Triad3A immunogold labeling near the membrane and on vesicle-like structures in BOTH presynaptic terminals and postsynaptic spines (Figure 6E). 23/10/2017 Pim - Authors mention: "Triad3A labeling was present at membrane sites and vesicular structures in both presynaptic terminals (T) and postsynaptic spines (S)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 682 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |