| Annotated protein: | Leucine-rich repeat transmembrane neuronal protein 4. Gene symbol: LRRTM4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80XG9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRRTM4 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse assembly (GO:0051963) |
| Synapse type(s): | hippocampus, glutamatergic neocortex, glutamatergic |
| Annotated paper: | de Wit J, et al. "Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development" Neuron. 2013 Aug 21;79(4):696-711 PMID:23911103 |
| Figure(s): | Fig. 3c,d |
| Annotation description: | - Overexpression of LRRTM4-Fc decreases excitatory synapse density in DIV14 hippocampal neurons (Figure 5, Myc-tagged LRRTM4). - Synaptogenic activity of LRRTM4 in HEK cells (Figures 6A-6D). (HEK cells, Myc-tagged LRRTM4). - LRRTM4 knockdown significantly decreases the density of dendritic protrusions in vivo and reduced synaptic currents (ctx neurons, shRNA KD). 24/5/2017 Pim - All points to a role of LRRTM4 in synapse assembly (aka synapse formation) via a trans-synaptic interaction with GPC4. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Chiara Verpelli (ORCID:0000-0003-2949-9725) Carlo Sala (ORCID:0000-0003-0662-9523) |
| Lab: | CNR Neuroscience Institute Milan and Dept. of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy |
| SynGO annotation ID: | 679 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |