| Annotated protein: | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13). Gene symbol: PRKCG. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63318 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRKCG |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synaptic vesicle exocytosis (GO:2000300) |
| Synapse type(s): | Calyx of Held |
| Annotated paper: | Chu Y, et al. "Calcium-dependent PKC isoforms have specialized roles in short-term synaptic plasticity" Neuron. 2014 May 21;82(4):859-71 PMID:24794094 |
| Figure(s): | Fig 5, 6 |
| Annotation description: | It is demonstrated that PKC gamma controls post-tetanic potentiation in the juvenile calyx of Held. Since it does not regulate pool size (figure 5) or calcium influx (figure 6), it must regulate the probability of Ca2+-dependent fusion. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Microscopy (generic) Whole-cell patch clamp |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| SynGO annotation ID: | 67 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |