| Annotated protein: | Cytoplasmic polyadenylation element-binding protein (CPE-binding protein) (CPEB). Gene symbol: . Taxonomy: Aplysia californica (California sea hare). Uniprot ID: Q967R6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CPEB1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of translation at synapse, modulating synaptic transmission (GO:0099547) |
| Synapse type(s): | brain, serotonergic |
| Annotated paper: | Si K, et al. "A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia" Cell. 2003 Dec 26;115(7):893-904 PMID:14697206 |
| Figure(s): | Fig. 6 |
| Annotation description: | CPEB, and specifically synaptic CPEB, is needed for long-term facilitation (LTF) in Aplysia, as evidenced by inhibition of CPEB expression using an antisense oligo. Note that Aplysia has probably only one CPEB family member, i.e., it is not self-evident that the functional orthologue of ApCPEB (in this instance) is CPEB3 rather than CPEB1 or CPEB4. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Field recordings Electrophysiology (generic) |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| Additional literature: | AcBPEB binds mRNA @ PMID:23435382 AcCPEB is a translation activator @ PMID:21270333 |
| SynGO annotation ID: | 654 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |